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Leucidal Liquid Complete *

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Leucidal® Liquid Complete combines the antibacterial power of Leucidal® Liquid and the antifungal power of AMTicide® Coconut to deliver an effective and convenient one step solution! This highly marketable product can provide moisturizing and conditioning benefits in hair and skin care applications. Leucidal® Liquid Complete is effective at preventing the growth of bacteria and fungi, including yeast and mold, making it the perfect addition to any formulation.

Leucidal® Liquid Complete is a mixture of antimicrobial peptide technology. One type of the antimicrobial peptides is originally derived from the lactic acid bacteria, Leuconostoc kimchii. L. kimchii is one of 15 species of microorganisms that make up the mixed culture used for producing the Korean dietary staple known as kimchi, a type of fermented cabbage. L. kimchii is capable of restricting the growth of other microorganisms by acidifying its environment, but as is common in nature, it is not content to limit itself to a single mechanism of defense. In addition to acidifying its environment, it also produces a novel antimicrobial peptide. Using modern fermentation and bioprocessing technology, Active Micro Technologies has commercialized this antimicrobial peptide to produce Leucidal® Liquid Complete.

The other type of antimicrobial peptide is created from fermenting Cocos nucifera (Coconut) with Lactobacillus. Coconut oil has been traditionally used to treat skin disorders, yeast infections, ringworm, and even athlete’s foot. About 50% of the total fatty acid content of coconut oil are medium chain triglycerides (MCT’s) that exhibit natural antifungal activity. MCT’s, such as lauric acid, work by disrupting the cellular structures of fungus and destroying them before they can wreak havoc. During the fermentation process, lipopeptides are catabolized by the MCT’s present in coconut flesh. Active Micro Technologies has harnessed natural phytocompounds and lipopeptides from coconut to produce a novel antifungal material.

Natural antimicrobial products are similar to synthetic preservative systems in that they are effective against bacteria, however most natural antimicrobial products lack broad-spectrum effectiveness against bacteria and fungi, specifically yeast and mold. Leucidal® Liquid Complete uses a combination of peptide technology to deliver moisturizing and conditioning benefits as well as providing broad-spectrum activity to protect against bacteria, yeast, and mold in one product.

A skin moisturization study was performed using an untreated control, generic cream base, and an experimental with the same cream base containing 2.0% Leucidal® Liquid Complete. The average increase in moisturization is in Figure 1 below.

Comparative moisturization results from this study are shown in Figure 2. As demonstrated by the results of this study, the addition of 2.0% Leucidal® Liquid Complete improved moisture levels by 42.01% after 24 hours and by 62.33% after four weeks when compared to the untreated control. When compared to the base cream Leucidal® Liquid Complete improved moisturization by 14.38% and after 24 hours and by 24.13% after four weeks. Based on these results, adding this innovative product provides the formulator the opportunity to capitalize on both the natural antimicrobial properties of Leucidal® Liquid Complete, as well as its ability to provide potent moisturizing benefits to the cosmetic formulation. These properties make it ideal for applications addressing numerous skin and scalp conditions.

One of the first steps in the development of Leucidal® Liquid Complete was to determine the product’s potential ability to inhibit the growth of a variety of bacteria and fungi. Using standard serial dilution protocols in growth media, the Minimum Inhibitory Concentrations (MICs) for Leucidal® Liquid Complete were determined for a variety of bacterial and fungal organisms. The results of these tests are shown in Figure 3.

The positive MIC screening results warranted further testing to confirm its ability to provide product preservation. A Double Challenge Test was completed using 2.0% Leucidal® Liquid Complete in a generic cream base formulation. Samples were inoculated with E. coli, P. aeruginosa, S. aureus, C. albicans, and A. brasiliensis. During the first 28-day incubation period, samples were periodically collected and tested for the presence of these microorganisms. Following this initial 28 days of incubation, the cream samples were then re-inoculated with the microbial cultures and sampled over an additional 28-day period. Figure 4 shows the positive preservation results for Leucidal® Liquid Complete.

As with all biological materials, attention must be paid to the conditions under which Leucidal® Liquid Complete is used. Based on bench-scale evaluations, as well as actual product applications, Leucidal® Liquid Complete has been found to be effective over a wide range of typical cosmetic and personal care product manufacturing conditions. Leucidal® Liquid Complete has been found to be heat stable up to70°C and active under both acidic (pH 3) and basic (pH 8) conditions.

Leucidal® Liquid Complete can be hazy at cooler temperatures, therefore it is recommended to warm the full container of product to 35-40°C and mix until clear prior to use.

INCI Nomenclature: Leuconostoc/Radish Root Ferment Filtrate & Lactobacillus & Cocos Nucifera (Coconut) Fruit Extract

Suggested Use Levels: 2-4%
Appearance: Hazy Liquid
Solubility: Water Soluble
pH: 5.0-9.0

Storage: Protected from direct light and humidity at a temperature of 50°-77°F (10°-25°C)

Shelf life: 12 months, properly stored, in sealed container. This product should be added to a formulation at the recommended usage rate